Strongest Numbing Creams In The World (2022) [FDA]

You may hear about the strongest numbing creams that work so fast and make the pain bearable. However, the selection of the strongest numbing cream can be a tough thing to do. The reason is there are many numbing creams available in the market. But you want an attractive tattoo on your body without going through a painful process.

In simple words, you have to find the strongest topical anesthetic cream that contains the highest amount of lidocaine and numbs the skin without any side effects. Therefore, we’ve analyzed every strongest lidocaine cream and got the strongest tattoo numbing creams of 2022 for you. We have reviewed these creams and also mentioned all the pros and cons to cover all the properties.

So, you can make an excellent choice and get the best tattoos with comfort. Moreover, these best topical anesthetic creams are approved by the food and drug administration.

Ebanel Strongest Topical Numbing Cream
Ebanel 5% Lidocaine★★★★★
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Uber Numb Strongest Lidocaine Cream
Uber Numb 5% Lidocaine★★★★★
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Numb Master Over The Counter Lidocaine Cream
Numb Master 5% Lidocaine★★★★
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Strongest Topical Anesthetic – Top 3 Picks For Lidocaine Cream

1 Ebanel Numb 520 – Strongest Topical Anesthetic Numbing Cream

Ebanel 5% Lidocaine Topical Numbing Creams

Ebanel’s fast-working Numb 520 cream gives temporary comfort from local and anorectal dysfunctions or inflammation. This strongest topical anesthetic cream is manufactured in FDA registered (ISO 13485 certified) facility under strict instructions. Therefore, it comes in protected childproof packaging.

Ebanel Numb 520’s rare combination of botanical ingredients helps decrease skin redness and swelling. By summarizing lidocaine into a liposome, it can absorb well in the skin and increase the numbing effect. That makes it the strongest numbing cream.

Lidocaine HCl is an active ingredient. That temporarily blocks the pathway of pain signals with nerves and helps to make a pain-free character. The numbing effect is so strong that you can defeat pain and discomfort immediately. Also, this strongest topical anesthetic cream allows your body to heal quickly as we experienced.

Before starting to use this tattoo numbing cream, clean the skin area with antibacterial tattoo soap and warm water. Then dry it with a soft cloth. Don’t forget to wear gloves to keep your fingers safe.

Now, apply a heavy layer of this strongest tattoo numbing cream about a ¼ inch to avoid evaporation. Because Ebanel Numb 520 is water-based numbing cream. Gently spread it onto the skin. Cover the skin area and cream with plastic wrap and for 30 minutes. Remove the wrapper and wipe the cream off the skin.

You’ll be surprised because the numbing effect will take place within 20-30 minutes. For peak output, use Numb 520 for at least 60 minutes.

We found its numbing effect remains for 1-2 hours. Some users reported that the effect lasts up to 4 hours in sensitive skin cases. This strongest numbing cream is ideal for people with thick or rough skin. Many repeats of Ebanel Numb 520 cream in a single day are not suitable.

This strongest topical numbing cream is one of the best topical tattoo numbing creams in 2022 for being nongreasy and nonmessy. Also, Ebanel numb 520 is useful for all types of skin.

Many lidocaine creams have an unpleasant smell, but Ebanel Numb 520 strongest numbing cream is odorless. This property makes it perfect for a pleasant tattoo session. It is also helpful in other procedures like waxing, piercing, and laser hair removal. Moreover, this numbing cream has even been used to operate hemorrhoids.

1.35 Ounces
Ebanel Laboratories

  • Ebanel Numb 520 cream has 5% Lidocaine.
  • Also, it is free of harsh chemical ingredients.
  • It gives a long-lasting numbing effect for up to 2-3 hours.
  • The FDA approved this numbing cream.
  • Moreover, it reduces swelling, redness, itching, and gives instant relief.
  • This strongest topical anesthetic cream has anti-inflammatory properties.
  • Further, it is suitable for all skin types as we tested.
  • Last but not least, it does not make your skin slippery because of its non-greasiness.
  • In some cases, this strongest topical numbing cream took more than 30 minutes to work.
  • Not suitable for micro-blading.

2 Uber Numb – Strongest Lidocaine Cream

Uber Numb 5% Lidocaine Topical Numbing Cream

Uber Numb is an American tattoo numbing cream. It is the best-selling numbing cream for tattoos and has +13,000 positive reviews on Amazon. Most importantly, it is the strongest numbing cream because of its rapid-acting topical painkiller formula.

In both tattooing and tattoo removal procedures, we can use this strongest lidocaine cream. Also, We’ll start noticing the resemblance as we begin reading all the articles on the best tattoo numbing creams in 2022. Hence, Uber Numb is globally famous and earned a name. It contains vitamin E and 5% lidocaine.

For tattoo sessions, vitamin E implants and perfects the skin. Vitamin E is an anesthetic and also modifies the skin. Moreover, we found this strongest lidocaine cream can heal the cut. You’ll not face ink issues or tattoo dryness.

The Uber Numb cream also has propylene glycol. That is why lidocaine completely absorbs, and skin penetration increases. Another best thing about Uber Numb is nonoily and nongreasy cream. Further, its strongest numbing effect keeps you active in the tattoo process.

This strongest topical anesthetic cream comes in a premium branding within two quantities: 2 oz and 4 oz. You can use it for just 1 hour before going to the tattoo studio. Apply this cream on the skin, and cover it entirely. As we know, everybody has different skin.

So the average duration of Uber Numb’s effect is about 1-3 hours as we experienced. In a few sensitive skin cases, the numbing effect lasts up to 4 hours.

Therefore, many professional artists advise using Uber Numb before getting a tattoo. The bottom line is that Uber Numb is the most trusted strongest tattoo numbing cream in 2022.

2 Ounces
4 Ounces
Uber Scientific

  • Uber Numb cream contains a maximum dose of lidocaine that is 5%.
  • It has skin-beneficial active ingredients.
  • Also, this strongest lidocaine cream is suitable for all skin types.
  • Moreover, it is the best choice for nervous skin area tattoos.
  • Uber Numb cream prevents irritation, itching, and inflammation.
  • Further, we found it non-oily and non-greasy.
  • The company gives cash back guarantee of this strongest numbing cream.
  • Last but not least, this strongest topical anesthetic cream gives long-lasting pain relief.
  • You have to apply it at least 1 hour ago before getting a tattoo.

3 Numb Master –  Topical Strong Numbing Cream

Numb Master 5% Lidocaine Topical Numbing Creams

Numb Master is the best pick for your tattoo session preparation. It is the most acclaimed tattoo-numbing cream. Also, this strong numbing cream comes at an affordable price. The highlight of this strongest numbing cream is 5% lidocaine. This quantity is an approved maximum amount by the FDA.

This strongest over-the-counter lidocaine cream is water-based. It has many other beneficial properties like non-sticky and non-greasiness. Also, Numb Master doesn’t leave any stains on the cloth. The slipping of the tattoo machine needle in the tattoo session can cause a fumble design or even an injury.

Therefore, many tattoo artists like us suggest this strongest over-the-counter lidocaine cream over the years because it would not make the skin oily.

People are using lidocaine as a local pain killer since 1943. Lidocaine makes the pain signals weak. So, sodium will not enter the nerve endings. That is why all the best tattoo numbing creams use lidocaine. All the pain-reducing process happens quickly when you apply numbing cream properly.

Numb Master starts working within 20 minutes. Make sure you follow all the given instructions. Start with clean the skin with warm water and soothing soap. Then, dry the skin with soft tissue or cloth. Now, apply a heavy layer of Numb Master cream and cover it up. The plastic wrap stops evaporation.

As a result, skin penetration will increase. At last, remove the cover after 30 minutes as we did. Finally, you’ll feel the numbing effect.

This strongest numbing cream of 2022 also works smoothly in all procedures of broken skin. If you have an allergy problem, you can check out all the ingredients. Hopefully, this strong numbing cream wouldn’t have any allergic elements. In short, Numb Master cream keeps your skin numb for the perfect tattoo.

1 Ounce
4.2 Ounces
Clinical Resolution Laboratory

  • Numb Master tattoo numbing cream is the only cream that has liposomal technology for the maximum result of 5% lidocaine.
  • The FDA approved this strongest numbing cream.
  • Also, it removes redness, itching, swelling, and irritation if have any.
  • Moreover, this strongest over-the-counter lidocaine cream is suitable for all skin types.
  • There will be no difficulty in getting a tattoo because of its non-stick property.
  • The numbing effect of this strongest topical anesthetic cream only stays for 1-2 hours.

FAQs of Strongest Numbing Creams

What Is The Strongest Numbing Cream?
Ebanel Numb 520 is the strongest numbing cream for tattoos. It has 5% lidocaine which is the maximum amount of lidocaine that the FDA approved. Also, this cream works for up to 3-4 hours. Moreover, its botanical ingredients prevent redness and swelling.
What Is The Strongest Topical Anesthetic?
Tetracaine is the strongest topical anesthetic of all. Topical anesthetics are used in many procedures. But for numbing the skin for tattoos, lidocaine is the best choice. In simple words, lidocaine is a little less strongest than tetracaine.
What Is The Strongest Lidocaine?
You can find many products with the strongest lidocaine which is 10-20% lidocaine. But this amount is bad for the skin. Only choose the product with 5% lidocaine.
What Is The Best Over The Counter Numbing Cream?
Ebanel Numb 520 is the best over the counter numbing cream. There can be many duplicates of this cream. However, you can find it online with genuine quality.
Is It Bad To Put Numbing Cream On Before A Tattoo?
The answer is NO. Also, the numbing cream is meant to be applied before getting a tattoo. The numbing cream will make the pain bearable or remove it temporarily. Therefore, you can enjoy your tattoo session without feeling pain.


We aim to give you honest reviews and the best numbing creams for tattoos. Our pick for the strongest numbing cream in 2022 is Uber Numb 5% Lidocaine Topical Numbing Cream ( +13,000 Reviews ).

We did all the work for your best experience of the tattoo session. We told you all the pros and cons. That will help you to understand how all the numbing creams work. All over the world, these best tattoo numbing creams have built trust among tattoo artists and collectors.

We all love tattoos. Therefore, numbing creams for tattoos are nothing less than a gift for us. We guarantee that you’ll love our recommendations after purchasing them.

For more information or questions, you can comment in the below section. Please share our article with your colleagues who’d also love to get tattoos.


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